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A rapid and sensitive LC-MS/MS method for simultaneous determination of melphalan and its monohydroxy and dihydroxy metabol ... 1 1 Introduction 1 2 Materials and methods 2 2.1 Chemicals and reagents 2 2.2 Preparation of stock solutions, standard solutions, and quality control samples 2 2.3 Sample preparation 2 2.4 Instrumentation and conditions 2 2.5 Method validation 5 2.6 Application to clinical samples 5 3 Results and discussion 5 3.1 Method development 5 3.2 Method validation 5 3.2.1 Specificity 5 3.2.2 Carry-over 6 3.2.3 LLOQ and calibration curve 6 3.2.4 Accuracy and precision 6 3.2.5 Recovery and matrix effect 6 3.2.6 Stability 6 3.3 Application to clinical samples 8 4 Conclusion 8 CRediT authorship contribution statement 8 Declaration of Competing Interest 8 Data availability 8 Acknowledgements 8 References 8
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It is typically read by self-directed learners exploring a subject in depth.
Common subject areas: history, science, philosophy, social sciences.
- Language
- EN
- Category
- nonfiction
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