Interspecies Scaling of Tolcapone, a New Inhibitor of Catechol-o-methyltransferase (comt). Use of in Vitro Data from Hepatocytes to Predict Metabolic Clearance in Animals and Humans

Th. Lave, S. Dupin, M. Schmitt, M. Kapps, J. Meyer, B. Morgenroth, R. C. Chou, D. Jaeck & Ph. Coassolo