S1066 Oral Alpha-4 Integrin Inhibitor (AJM300) in Patients with Active Crohn's Disease — A Randomized, Double-Blind, Placebo-Controlled TrialTakazoe · Gastroenterology2009PDF100 KB
Oral Treatment with a Novel Small Molecule Alpha 4 Integrin Antagonist, AJM300, Prevents the Development of Experimental Colitis in MiceSugiura · Journal of Crohn s and Colitis2013PDF664 KB
Safety and Efficacy of AJM300, an Oral Antagonist of α4 Integrin, in Induction Therapy for Patients with Active Ulcerative ColitisYoshimura · Gastroenterology2015PDF1.5 MB
370 AJM300, an Oral A4 Integrin Antagonist, for Active Ulcerative Colitis: a Multicenter, Randomized, Double-blind, Placebo-controlled Phase 2a StudyWatanabe · Gastrointestinal Endoscopy2014PDF69 KB
370 AJM300, an Oral α4 Integrin Antagonist, for Active Ulcerative Colitis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2A StudyWatanabe · Gastroenterology2014PDF126 KB
AJM300, a novel oral antagonist of α4‐integrin, sustains an increase in circulating lymphocytes: a randomised controlled trial in healthy male subjectsFukase · British Journal of Clinical Pharmacology2019PDF1.6 MB
AJM300, a novel oral antagonist of α4‐integrin, sustains an increase in circulating lymphocytes: A randomised controlled trial in healthy male subjectsFukase · British Journal of Clinical Pharmacology2020PDF1.6 MB
M1647 An Orally Active Alpha4 Integrin Antagonist AJM300 Prevents the Development of Experimental Colitis Induced By Adoptive Transfer of IL-10 Deficient CD4+ T Cells in MiceSugiura · Gastroenterology2009PDF49 KB
A Novel, Orally Active Alpha 4 Integrin Antagonist, AJM300 Prevents the Development of Experimental Colitis Induced by Adoptive Transfer of IL-10 Deficient CD4+ T Cells in Mice.Sugiura · American Society for Pharmacology & Experimental Therapeutics (ASPET)2012PDF46 KB
An Orally Available Alpha 4 (α4) Integrin Antagonist AJM300 Increases the Peripheral Lymphocyte Counts: The Relationship Between Pharmacokinetics/Pharmacodynamics (PK/PD) and Efficacy Against Colitis Model in MiceSugiura · Gastroenterology2011PDF41 KB