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Multi-objective optimization for gene expression noise reduction in a synthetic gene circuit * *This work is partially supported by Spanish government and European Union (FEDER-CICYT DPI2014-55276-C5-1). Y.B. thanks grant FPI/2013-3242 of Universitat Politècnica de València, and also thanks the support from the Ayudas para movilidad dentro del Programa para la Formación de Personal Investigador…Boada, Y.IFAC-PapersOnLine2017DOI 10.1016/j.ifacol.2017.08.376