Can I read Antiepileptic Drugs in Patients With Liver Disease on EtoBox?

Antiepileptic Drugs in Patients With Liver Disease by Ali A. Asadi-Pooya; Michael R. Sperling is a book available to read on EtoBox.

What is Antiepileptic Drugs in Patients With Liver Disease about?

The use of antiepileptic drugs (AEDs) in the presence of liver diseases and hepatic dysfunction is associated with an increased risk of adverse e ects. Knowledge of the mechanisms of metabolism and elimination of these drugs is crucial when selecting an AED in epilepsy patients with liver disease. The use of antiepileptic drugs (AEDs) in the presence of liver diseases and hepatic dysfunction is associated with an increased risk of adverse e ects. Knowledge of the mechanisms of metabolism and elimination of these drugs is crucial when selecting an AED in epilepsy patients with liver disease. Loss of hepatocytes and disruption of liver blood ow may alter the metabolism of some AEDs. Hypoalbuminemia and impaired metabolism by cytochrome P-450 and glucuronyl transferase enzymes may increase free AED levels (Lacerda et al., 2006). The type of hepatic disease may also preferentially a ect some enzyme systems; for example, CYP3A4 is a ected more in hepatocellular dysfunction, and CYP2E1 is a ected more in cholestasis. Unlike renal failure, which can be quanti ed, liver disease is not easily quanti able, so adjustments in dosing are more di cult. Fortunately, even moderate liver dysfunctio

Author

Ali A. Asadi-Pooya; Michael R. Sperling

Publisher

Oxford University Press

Published

2015

Language

EN