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Nucleic Acid–Metal Ion Interactions by Sergei A. Kazakov; Sidney M. Hecht is a book available to read on EtoBox.

What is Nucleic Acid–Metal Ion Interactions about?

## Abstract Nucleic acids (DNA and RNA) are actually salts (or complexes) of metal ions from a chemical point of view. It is impossible to separate the behavior of DNA and RNA from their interactions with metal ions. Metal ions are usually required to promote and stabilize functionally active or native conformations of nucleic acids, as well as to mediate nucleic acid‐protein interactions. However, certain metal ions can also cause structural transformation of nucleic acids, and induce their chemical modification and cleavage. Metal‐nucleic acid interactions are involved in nucleotide biochemistry; genetic information storage and transfer, and control of gene expression, as well as in mutagenesis and carcinogenesis. However, in most cases, it is not currently clear whether the observed effects actually result from direct metal ion‐nucleic acid interaction, since other species, such as specific proteins, may be mediators between the metal ion and the nucleic acid in these processes __in vivo__ . Interest in metal‐nucleic acid interactions is also enhanced by studies of the mechanisms of antitumor activity of certain platinum metal compounds, finding metal ions in crystal structure o

Author

Sergei A. Kazakov; Sidney M. Hecht

Publisher

John Wiley & Sons, Incorporated

Published

2005

Language

EN

ISBN

9780470862100

Subjects

Science, Chemistry, Stem