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The subthalamic nucleus and the placebo effect in Parkinson's disease by Elisa Frisaldi; Denisa Adina Zamfira; Fabrizio Benedetti is a book available to read on EtoBox.

What is The subthalamic nucleus and the placebo effect in Parkinson's disease about?

The study of the placebo effect, or response, is related to the investigation of the psychologic component of different therapeutic rituals. The high rate of placebo responses in Parkinson's disease clinical trials provided the impetus for investigating the underlying mechanisms. Ruling out spontaneous remission and regression to the mean through the appropriate experimental designs, genuine psychologic placebo effects have been identified, in which both patients' expectations of therapeutic benefit and learning processes are involved. Specifically, placebo effects are associated with dopamine release in the striatum and changes in neuronal activity in the subthalamic nucleus, substantia nigra pars reticulata, and motor thalamus in Parkinson's disease, as assessed through positron emission tomography and single-neuron recording during deep brain stimulation, respectively. Conversely, verbal suggestions of clinical worsening or drug dose reduction induce nocebo responses in Parkinson's disease, which have been detected at both behavioral and electrophysiologic level. Important implications and applications emerge from this new knowledge. These include better clinical trial designs,

Author

Elisa Frisaldi; Denisa Adina Zamfira; Fabrizio Benedetti

Publisher

Elsevier

Published

2021

Language

EN

ISBN

9780128206836

Subjects

Science, Medical, Medicine