Can I read Modeling Parkinson's Disease in Primates on EtoBox?

Modeling Parkinson's Disease in Primates by Erwan Bezard,1,2,3 Margaux Teil,1 Marie-Laure Arotcarena,1 Gregory Porras,2 Qin Li,3nd Benjamin Dehay3 is a book available to read on EtoBox.

What is Modeling Parkinson's Disease in Primates about?

Decades of research have identified the pathological and pathophysiological hallmarks ofParkinson’s disease (PD): profound deficit in brain dopamine and other monoamines, pathological α-synuclein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, altered energy homeostasis, inflammation, and neuronal cell death. The purpose ofthis contribution is to present the phenocopy aspect, pathogenic, and etiologic nonhumanprimate (NHP) models of PD to readers with limited prior knowledge of PD so that they areready to start working on PD. How NHPs, the closest species to man on which we can modeldiseases, contribute to the knowledge progress and how these models represent an invaluabletranslational step in therapeutic development are highlighted.PHENOMENOLOGY AND PATHOLOGYseveral years of disease progression, gait impairOF PARKINSON’S DISEASEments, balance problems, and freezing-of-gaitepisodes affect up to 90% of PD patients. SympThe first issue is to recognizewhatwe aimfor intomatic relief is also complicated over time by themodeling Parkinson’s disease (PD).4 PD isonset of motor fluctuations and L-dopa-inducedcharacterized, in part, by a progressive loss of

Author

Erwan Bezard,1,2,3 Margaux Teil,1 Marie-Laure Arotcarena,1 Gregory Porras,2 Qin Li,3nd Benjamin Dehay3

Published

2024

Language

EN