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Cytochrome P-450 : Structure, Mechanism, and Biochemistry by Paul Ortiz De Monetllano is a book available to read on EtoBox.

What is Cytochrome P-450 : Structure, Mechanism, and Biochemistry about?

Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de­ velopment of reliable procedures for the purification of membrane-bound enzymes, by the growing repertoire of molecular biological techniques, and by the development of chemical models that mimic the catalytic action of P-450. As a result, our understanding of the P-450 system is moving from the descriptive, pharmacological level into the tangible realm of atomic detail. The rapid progress and multidisciplinary character of the cytochrome P-450 field, which cuts across the lines that traditionally divide disciplines as diverse as inorganic chemistry and gen

Author

Paul Ortiz De Monetllano

Publisher

Springer

Published

2013

Language

EN

ISBN

9781475799392

Subjects

Science, Chemistry, Medical