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Pharmaceutical Biocatalysis; Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients; Edition 1 by Grunwald, Peter (editor) is a nonfiction available to read on EtoBox.

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This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthe

Who reads Pharmaceutical Biocatalysis; Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients; Edition 1?

Author

Grunwald, Peter (editor)

Publisher

Jenny Stanford Publishing

Published

2019

Language

EN

ISBN

9781000707311

Category

nonfiction

Subjects

Medical, Science, Technology