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Design, synthesis, biological evaluation, and molecular docking study of thioxo-2,3-dihydroquinazolinone derivative as tyrosinase inhibitors 1 1 Introduction 1 2 Results and discussion 2 2.1 Designing consideration 2 2.2 Chemistry 2 2.3 Evaluation of tyrosinase inhibitory activity and structure-activity relationship 2 2.4 Kinetic studies of enzyme inhibition 5 2.5 Binding interactions between compound 4m and tyrosinase 5 2.6 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant assay 6 2.7 Physicochemical and ADME-Tox properties assessments 6 3 Conclusion 6 4 Material and method 6 4.1 Chemistry 6 General Experimental Procedure for 2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives 6 3-phenyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (4a) [42-44] 6 3-(4-fluorophenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (4b) 7 3-(4-chlorophenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (4c) [45,46] 7 2-thioxo-3-(p-tolyl)-2,3-dihydroquinazolin-4(1H)-one (4d) [42] 7 3-(4-methoxyphenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (4e) [42] 8 3-benzyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (4f) [45,47] 8 3-(4-fluorobenzyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one (4g) 8 3-(4-methylbenzyl)-2-thioxo-2,3-di

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nonfiction