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Synthesis, antiproliferative, docking and DFT studies of benzimidazole derivatives as EGFR inhibitors 1 1 Introduction 1 2 Experimental 2 2.1 General 2 2.2 Chemistry 2 2.2.1 General procedure for the synthesis of 2-(4-{[1-substitutedaryl)-1H-1,2,3-triazol-4-yl]methoxy}-3-methoxyphenyl)-1H-benzimidazole (5a-j) 2 2.2.2 2-(4-{[1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl]methoxy}-3-methoxyphenyl)-1H-benzimidazole (5a) 2 2.2.3 2-(4-{[1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl]methoxy}-3-methoxyphenyl)-1H-benzimidazole (5b) 2 2.2.4 2-(4-{[1-(3-bromophenyl)-1H-1,2,3-triazol-4-yl]methoxy}-3-methoxyphenyl)-1H-benzimidazole (5c) 2 2.2.5 2-(4-{[1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl]methoxy}-3-methoxyphenyl)-1H-benzimidazole (5d) 2 2.2.6 2-(4-{[4-(1H-benzimidazol-2-yl)-2-methoxyphenoxy]methyl}-1H-1,2,3-triazol-1-yl)benzoic acid (5e) 2 2.2.7 2-(4-{[1-(2,4-dichlorophenyl)-1H-1,2,3-triazol-4-yl]methoxy}-3-methoxyphenyl)-1H-benzimidaz ole (5f) 2 2.2.8 2-(4-{[1-(o-tolyl)-1H-1,2,3-triazol-4-yl]methoxy}-3-methoxyphenyl)-1H-benzimidazole(5g) 2 2.2.9 2-(4-{[1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl]methoxy}-3-methoxyphenyl)-1H-benzimidazo le (5h) 3 2.2.10 2-(4-{[1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl

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