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Epigenetic Therapy of Cancer [recurso electrónico] Preclinical Models and Treatment Approaches by Manuel Rodríguez-Paredes, Manel Esteller (auth.), Michael Lübbert, Peter A. Jones (eds.) is a nonfiction available to read on EtoBox.

What is Epigenetic Therapy of Cancer [recurso electrónico] Preclinical Models and Treatment Approaches about?

The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail. Erscheinungsdatum: 15.01.2014

Who reads Epigenetic Therapy of Cancer [recurso electrónico] Preclinical Models and Treatment Approaches?

Author

Manuel Rodríguez-Paredes, Manel Esteller (auth.), Michael Lübbert, Peter A. Jones (eds.)

Publisher

Springer-Verlag Berlin Heidelberg

Published

2014

Language

EN

ISBN

9783642384035

Category

nonfiction

Subjects

Medical, Medicine