Can I read Improving Cancer Survival Through Perioperative Attenuation of Adrenergic-Inflammatory Signaling on EtoBox?

Improving Cancer Survival Through Perioperative Attenuation of Adrenergic-Inflammatory Signaling by Itay Ricon-Becker; Jonathan G. Hiller; Shamgar Ben-Eliyahu is a book available to read on EtoBox.

What is Improving Cancer Survival Through Perioperative Attenuation of Adrenergic-Inflammatory Signaling about?

Oncological surgery is a life-saving intervention, yet aspects of the perioperative period, including the surgical procedure itself, also promote progression of metastatic disease. Perioperative inflammation and stress responses, mediated through the abundant secretion of prostaglandins (PGs) and catecholamines (CAs), are prominent factors driving many of the prometastatic effects of the perioperative period. PGs and CAs exert synergistic prometastatic impacts through similar intracellular molecular pathways (e.g., cAMP-PKA-NF-κB), acting upon the malignant tissue, antimetastatic immunity, and metastases microenvironment, each through several known mechanisms. Animal studies provide robust evidence that perioperative inhibition of CA and/or PG signaling reduce metastatic progression and increase postoperative survival rate, and indicate that a combined blockade approach is markedly advantageous, as each factor independently is sufficient to exert deleterious effects. Clinical retrospective studies, assessing the use of either nonsteroidal antiinflammatory drugs (NSAIDs) or beta blockers, are heterogeneous and have provided inconclusive results that are cancer- and context-specific.

Author

Itay Ricon-Becker; Jonathan G. Hiller; Shamgar Ben-Eliyahu

Publisher

Elsevier - Health Sciences Division

Published

2023

Language

EN

ISBN

9780323695848