Can I read BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING on EtoBox?

BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING by Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao, is a book available to read on EtoBox.

What is BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING about?

Cervical cancer possesses high morbidity and mortality rates, and a1. IntroductionCervical cancer ranks as the fourth mostcomprehensive understanding of its molecular underpinnings is essential forprevalent malignant tumor among womenadvancing clinical management strategies. The innate immune sensor STING,worldwide, imposing a substantial burdenwhich activates type I interferon signaling, plays a pivotal role in enhancingon both public health and the economy.[1]anti-tumor activity. Despite increased attention to STING’s involvement inInfection with human papillomaviruscervical cancer, the regulatory mechanisms governing its protein homeostasis(HPV) is the primary etiological factor forcervical cancer, particularly high-risk HPVremain poorly understood. In this study, it is found that the BAG2-STUB1types, such as HPV16 and HPV18.[2] Thecomplex regulates ubiquitin proteasomal degradation of STING, which affectsoncogenic effects of these viruses are largelythe development of cervical cancer. Mechanistically, BAG2 inhibitsmediated by the E6 and E7 oncoproteins.[3]ubiquitination of STING and stabilizes it by interacting with STING.The HPV E6 protein accelerates the degraSpecifically, B

Author

Shijie Yao, Siming Chen, Anjin Wang, Ziyan Liang, Xuelian Liu, Yang Gao,

Published

2025

Language

EN