Can I read Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges on EtoBox?

Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges by Alina L. Capatina; Dimitris Lagos; William J. Brackenbury is a book available to read on EtoBox.

What is Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges about?

Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety of processes such as maintenance of cellular osmolarity and membrane potential, motility (via interactions with the cytoskeleton), invasion, signal transduction, transcriptional activity and cell cycle progression, leading to tumour progression and metastasis. Ion channels thus represent promising targets for cancer therapy. Ion channels are attractive targets because many of them are expressed at the plasma membrane and a broad range of existing inhibitors are already in clinical use for other indications. However, many of the ion channels identified in cancer cells are also active in healthy normal cells, so there is a risk that certain blockers may have off-target effects on normal physiological function. This review describes recent research advances into ion channel inhibitors as anticancer therapeutics. A growing body of evidence suggests that a range of existing and novel

Author

Alina L. Capatina; Dimitris Lagos; William J. Brackenbury

Publisher

Springer International Publishing : Imprint: Springer

Published

2022

Language

EN

ISBN

9783031039935

Subjects

Medical, Science, Chemistry