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Psychosocial stress increases risk for type 2 diabetes in female cynomolgus macaques consuming a western diet 1 1 Introduction 1 2 Materials and methods 2 2.1 Animal subjects 2 2.2 Experimental design (Supplementary Figure 1) 2 2.3 Behavior observations 2 2.3.1 Social behavior 2 2.4 Cortisol response 3 2.5 Anthropometrics 3 2.6 Body composition and fat distribution 3 2.7 Carbohydrate and lipid metabolism 3 2.8 Activity by actigraphy 3 2.9 Autonomic function 3 2.10 Statistical analysis 3 3 Results 4 3.1 Baseline characteristics (Supplementary Table 1) 4 3.2 Social status differences in behavior, cortisol, and nighttime activity (Fig. 1) 4 3.3 Body weight and composition (Supplementary Figures 2 and 3) 4 3.4 Social status differences in carbohydrate metabolism (Fig. 2) 4 3.5 Social status differences in heart rate variability (Fig. 3) 5 4 Discussion 5 5 Conclusion 7 Conflict of Interest Statement 7 Acknowledgements 7 Appendix A Supporting information 7 References 7

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Language

UND

Category

nonfiction