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Breakable foam of mupirocin for topical application on burn wounds: Statistical optimization and antimicrobial study 1 1 Introduction 1 2 Materials and methods 2 2.1 Materials 2 2.2 Solubility studies 2 2.3 Preparation of foam 2 2.4 Physicochemical characterization of pre-foam 2 2.5 Evaluation of a foam 2 2.5.1 Density and pH 2 2.5.2 Foam collapse time 2 2.5.3 Spreadability 2 2.5.4 Quality of Foam 3 2.6 Optimization of foam using design of experiments (DoE) 3 2.7 Viscosity of collapsed foam 3 2.8 In vitro release study 3 2.9 Antimicrobial efficacy 3 3 Results and discussion 4 3.1 Solubility of mupirocin and preparation of foam 4 3.2 Physicochemical characterization of pre-foam 4 3.3 Evaluation of foam characteristics 4 3.4 Optimization of the formulation 4 3.4.1 Collapse time 4 3.4.2 Density 6 3.5 Viscosity of collapsed foam 6 3.6 In vitro release study 6 3.7 Antimicrobial efficacy study 6 4 Conclusion 6 Funding 8 CRediT authorship contribution statement 8 Declaration of compting interest 8 Acknowledgment 8 Appendix A Supplementary data 8 References 8

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Language

UND

Category

nonfiction