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EPIDERMOLYSIS BULLOSA (EB) PREVALENCE, CLINICAL MANIFESTATIONS AND MANAGEMENT 2 EPIDERMOLYSIS BULLOSA (EB) PREVALENCE, CLINICAL MANIFESTATIONS AND MANAGEMENT 4 Library of Congress Cataloging-in-Publication Data 5 CONTENTS 6 PREFACE 8 Chapter 1 EPIDERMOLYSIS BULLOSA ACQUISITA 14 ABSTRACT 14 INTRODUCTION 15 HISTORY 16 EPIDEMIOLOGY 16 ETIOLOGY 17 PATHOGENESIS 17 CLINICAL PRESENTATION 18 Clinical Phenotypes 18 EBA and Associations with Other Diseases 20 DIAGNOSIS 21 TREATMENT 24 Current Treatment Options for EBA 25 Future Treatment Modalities 26 PROGNOSIS AND PROFILAXIS 27 REFERENCES 27 Chapter 2 IMMUNOFLUORESCENCE MAPPING FOR DIAGNOSIS OF INHERITED EPIDERMOLYSIS BULLOSA 40 ABSTRACT 40 INTRODUCTION 41 Immunofluorescence Mapping 42 Biopsy Technique 43 Antibodies 44 Staining Procedure 45 Interpretation of Results 45 Epidermolysis Bullosa Simplex (EBS) 46 Junctional Epidermolysis Bullosa (JEB) 47 Dystrophic Epidermolysis Bullosa (DEB) 47 Kindler Syndrome 48 Prenatal Diagnosis 48 CONCLUSION 48 REFERENCES 49 Chapter 3 NUTRITION FOR CHILDREN AND ADOLESCENTS WITH EPIDERMOLYSIS BULLOSA 52 ABSTRACT 52 INTRODUCTION 53 NUTRITIONAL REQUIREMENTS 55 Ene
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