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Through their effects on carbonic anhydrase in the proximal tubule, CAIs increase bicarbonate excretion by 25À30% (see Table 40.1). Chronic CAI administration, however, causes only a modest natriuresis, despite the magnitude of carbonic anhydrase-dependent proximal Na reabsorption. Several factors account for this. First, carbonic anhydrase is required for reabsorption of HCO 3 2 , whereas about two thirds of the proximal Na 1 reabsorption is accompanied by Cl 2 . Second, some proximal HCO 3 2 reabsorption persists 1357 PROXIMAL TUBULE DIURETICS III. FLUID AND ELECTROLYTE REGULATION AND DYSREGULATION

Author

David H. Ellison

Publisher

Elsevier

Published

2013

Language

EN