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Hypertension: Physiology and Pathophysiology by John E. Hall; Joey P. Granger; Jussara M. do Carmo; Alexandre A. da Silva; John Dubinion; Eric George; Shereen Hamza; Joshua Speed; Michael E. Hall is a book available to read on EtoBox.

What is Hypertension: Physiology and Pathophysiology about?

## Abstract Despite major advances in understanding the pathophysiology of hypertension and availability of effective and safe antihypertensive drugs, suboptimal blood pressure (BP) control is still the most important risk factor for cardiovascular mortality and is globally responsible for more than 7 million deaths annually. Short‐term and long‐term BP regulation involve the integrated actions of multiple cardiovascular, renal, neural, endocrine, and local tissue control systems. Clinical and experimental observations strongly support a central role for the kidneys in the long‐term regulation of BP, and abnormal renal‐pressure natriuresis is present in all forms of chronic hypertension. Impaired renal‐pressure natriuresis and chronic hypertension can be caused by __intrarenal__ or __extrarenal__ factors that reduce glomerular filtration rate or increase renal tubular reabsorption of salt and water; these factors include excessive activation of the renin‐angiotensin‐aldosterone and sympathetic nervous systems, increased formation of reactive oxygen species, endothelin, and inflammatory cytokines, or decreased synthesis of nitric oxide and various natriuretic factors. In human prima

Author

John E. Hall; Joey P. Granger; Jussara M. do Carmo; Alexandre A. da Silva; John Dubinion; Eric George; Shereen Hamza; Joshua Speed; Michael E. Hall

Publisher

Published For The American Physiological Society By Wiley Blackwell,

Published

2012

Language

EN

ISBN

9780470650714