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Aqueous extract of Polygala japonica Houtt. ameliorated nonalcoholic steatohepatitis in mice through restoring the gut micr ... 1 Introduction 2 Materials and methods 2 Reagents 2 Preparation of aqueous extraction of PJ 2 Animal experiment 2 Pathological staining 2 Biochemical testing 2 Enzyme-linked immunosorbent assay (ELISA) 2 16S rRNA sequencing 2 Liver and feces metabolomics 2 Correlation analysis 4 Statistical analysis 5 Results 5 PJ ameliorated liver injury and liver tissue lipid deposition in MCD-induced NASH mice 5 Effects of PJ on inflammation and oxidative stress in NASH mice 6 PJ improved the dysbiosis in MCD-induced NASH mice 6 PJ altered liver and fecal metabolite composition in MCD-induced NASH mice 7 Integrated analysis of gut microbiota with common metabolites in the feces and liver and pathological indicators 12 Discussion 12 Therapeutic, anti-inflammatory and anti-oxidative effects of PJ 12 Modulatory effects of PJ on gut microbiota 12 Modulatory effects of PJ on metabolites in feces and liver 12 Histidine metabolism 12 Tryptophan metabolism 13 Conclusions and future prospective 13 Funding 14 Declaration of Competing Interest 14 Data availability 14 Acknowledgmen

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nonfiction