Can I read Antiseizure Medications in Patients with Renal Disease on EtoBox?

Antiseizure Medications in Patients with Renal Disease by Ali A. Asadi-Pooya; Michael R. Sperling is a book available to read on EtoBox.

What is Antiseizure Medications in Patients with Renal Disease about?

Abstract The use of antiseizure medications (ASMs) in the presence of renal insufficiency is associated with an increased risk of adverse effects. Renal failure is often accompanied by other medical problems that can influence drug levels. These include gastroparesis, which slows absorption, and bowel edema, which may reduce absorption. There is often a decrease in gut cytochrome P-450 metabolism and P-glycoprotein active transport as well, which can affect how much of the drug enters portal circulation. Renal failure is also associated with hypoalbuminemia, which may influence free plasma concentrations of ASMs that are highly protein bound. Knowledge of the mechanisms of elimination of these drugs is crucial when selecting an ASM in patients with renal impairment.

Author

Ali A. Asadi-Pooya; Michael R. Sperling

Published

2022

Language

EN