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What is Bohr equation about?

Definition of terms used V d = physiological dead space V t = tidal volume P A CO 2 = alveolar partial pressure of CO 2 P E CO 2 = mixed expired partial pressure of CO 2 Units Nilit is a ratio.Normal ratio of dead space to tidal volume at rest is 0.2-0.35. Explanation The Bohr equation (Christian Bohr, 1855-1911) is used to derive the physiological dead space. It is given as a ratio of dead space to tidal volume. Its derivation (see below) is based on the fact that only ventilated alveoli involved in gas exchange will produce CO 2 , and none from the dead space.'Physiological dead space' differs from 'anatomical dead space' (measured by Fowler's method) as it measures the volume of the lung that does not eliminate CO 2 , and thus includes alveolar dead space. In health, however, the volumes are almost identical.In practice, P a CO 2 can be substituted for P A CO 2 and end-tidal CO 2 for P E CO 2 to use this equation. Clinical application/worked example 1. In a measurement of physiological dead space using Bohr's method, the alveolar and mixed expired PCO 2 were 5.3 and 4 kPa, respectively. What was the ratio of dead space to tidal volume?119Cambridge Core terms of use, available at

Author

Edward Gilbert-Kawai; Marc Wittenberg

Publisher

Cambridge University Press

Published

2014

Language

EN