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Fibroblast growth factors : biology and clinical application : FGF biology and therapeutics by Michael Simons, MD is a book available to read on EtoBox.

What is Fibroblast growth factors : biology and clinical application : FGF biology and therapeutics about?

"The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states. Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has b

Author

Michael Simons, MD

Publisher

World Scientific Publishing Co Pte Ltd

Published

2017

Language

EN

ISBN

9789813143364

Subjects

Medical, Science, Biology