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Nanobodies as Structural Probes of Protein Misfolding and Fibril Formation by Erwin De Genst; Christopher M. Dobson is a book available to read on EtoBox.

What is Nanobodies as Structural Probes of Protein Misfolding and Fibril Formation about?

The deposition of peptides and proteins as amyloid fibrils is a common feature of nearly 50 medical -disorders affecting the brain or a variety of other organs and tissues. These disorders, which include Alzheimer's disease, Parkinson's disease, the prion diseases, and type II diabetes, have an enormous impact on the public health and economy of the modern world. Extensive research is therefore taking place to determine the underlying molecular mechanisms and determinants of the pathological conversion of amyloidogenic proteins from their soluble forms into fibrillar structures. The use of molecular probes and biophysical techniques, such as X-ray crystallography and particularly NMR spectroscopy, are allowing detailed analysis of the mechanism of fibril formation and of the underlying structural and chemical features of the associated pathogenicity. Nanobodies, the antigen-binding domains derived from camelid heavy-chain antibodies, are excellent tools to probe protein aggregation as a result of their exquisite specificity and high affinity and stability, along with their ease of expression and small size; the latter in particular allows them to be used very efficiently in combina

Author

Erwin De Genst; Christopher M. Dobson

Publisher

Springer New York : Imprint: Humana Press

Published

2012

Language

EN

ISBN

9781617799686

Subjects

Medical, Science, Medicine