Can I read Citrulline Regulates Macrophage Metabolism and Inflammation to Counter Aging in Mice on EtoBox?

Citrulline Regulates Macrophage Metabolism and Inflammation to Counter Aging in Mice by x is a book available to read on EtoBox.

What is Citrulline Regulates Macrophage Metabolism and Inflammation to Counter Aging in Mice about?

Metabolic dysregulation and altered metabolite concentrations are widely recognized as key characteristics of agDistributed under a Creative Commons ing. Comprehensive exploration of endogenous metabolites that drive aging remains insufficient. Here, we conAttribution ducted an untargeted metabolomics analysis of aging mice, revealing citrulline as a consistently down-regulated NonCommercial metabolite associated with aging. Systematic investigations demonstrated that citrulline exhibited antiaging efLicense 4.0 (CC BY-­NC). fects by reducing cellular senescence, protecting against DNA damage, preventing cell cycle arrest, modulating macrophage metabolism, and mitigating inflammaging. Long-term citrulline supplementation in aged mice yielded beneficial effects and ameliorated age-associated phenotypes. We further elucidated that citrulline acts as an endogenous metabolite antagonist to inflammation, suppressing proinflammatory responses in macrophages. Mechanistically, citrulline served as a potential inhibitor of mammalian target of rapamycin (mTOR) activation in macrophage and regulated the mTOR–hypoxia-inducible factor 1α–glycolysis signaling pathway to counter inflammation

Author

x

Published

2025

Language

EN