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Eugenol derivatives with 1,2,3-triazole moieties: Oral treatment of cutaneous leishmaniasis and a quantitative structure-activity relationship model for their leishmanicidal activity by Róbson Ricardo Teixeira,Poliana Aparecida Rodrigues Gazolla,Maria Paula Gonçalves Borsodi,Márcia Miguel Castro Ferreira,Maria Cristina Andreazza Costa,Adilson Vidal Costa,Beatriz Cabral Abreu Grijó,Bartira Rossi Bergmann,Wallace Pacienza Lima is a nonfiction available to read on EtoBox.

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Experimental Parasitology, 238 (2022) 108269. doi:10.1016/j.exppara.2022.108269 Eugenol derivatives with 1,2,3-triazole moieties: Oral treatment of cutaneous leishmaniasis and a quantitative structure-ac ... 1 1 Introduction 1 2 Materials and methods 2 2.1 Compounds 2 2.2 Biological assays 2 2.2.1 Parasites 2 2.2.2 In vitro antileishmanial activity 2 2.2.3 Cytotoxicity against macrophages 2 2.2.4 Animals 3 2.2.5 In vivo antileishmanial efficacy 3 2.2.6 Statistical analysis 3 2.3 QSAR study 3 2.3.1 Conformational analysis 3 2.3.2 Partial least square (PLS) regression and principal component analysis (PCA) 3 3 Results and discussion 5 3.1 In vitro antileishmanial activity 5 3.2 In vivo studies 6 3.3 QSAR model for the leishmanicidal activity of eugenol derivatives 7 4 Conclusion 10 Credit author statement 10 Declaration of competing interest 10 Acknowledgment 10 Appendix A Supplementary data 10 References 10 Eugenol,"1,2,3-Triazoles",Leishmanicidal activity,Cutaneous leishmaniasis,Oral treatment,QSAR Eugenol,1,2,3-Triazoles,Leishmanicidal activity,Cutaneous leishmaniasis,Oral treatment,QSAR

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Author

Róbson Ricardo Teixeira,Poliana Aparecida Rodrigues Gazolla,Maria Paula Gonçalves Borsodi,Márcia Miguel Castro Ferreira,Maria Cristina Andreazza Costa,Adilson Vidal Costa,Beatriz Cabral Abreu Grijó,Bartira Rossi Bergmann,Wallace Pacienza Lima

Publisher

Elsevier Inc.

Language

EN

Category

nonfiction