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The 24th International Electronic Conference on Synthetic Organic Chemistry by Rodríguez-Gutiérrez, Sofía Vanessa (author);Barreiro-Costa, Olalla (author);León, Christian David Alcívar (author);Heredia-Moya, Jorge (author) is a nonfiction available to read on EtoBox.
What is The 24th International Electronic Conference on Synthetic Organic Chemistry about?
Leishmaniasis is a largely neglected infection caused by Leishmania spp. parasites. The first-line treatment, antimoniate meglumine, has a large number of adverse effects, high cost and is prone to resistance development, hence the necessity of new alternatives. We report the synthesis of (2E)-1-[1-(4-methoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl]-3-arylprop-2-en-1-one derivatives and the in vitro evaluation of their leishmanicidal activities. A series of 16 compounds were synthesized in three steps starting from p-anisidine with moderate to good yields and their biological activities were evaluated in vitro against Leishmania mexicana promastigotes and RAW 264.7 cells. The synthesis of 1,2,3-triazol and chalcone moieties were made using a cycloaddition with acetylacetone followed by a Claisen-Schmidt condensation using different substituted benzaldehydes. Nine compounds were active against L. mexicana with IC50 between 1.0 and 29.2 μM.
Who reads The 24th International Electronic Conference on Synthetic Organic Chemistry?
It is typically read by self-directed learners exploring a subject in depth.
Common subject areas: history, science, philosophy, social sciences.
- Author
- Rodríguez-Gutiérrez, Sofía Vanessa (author);Barreiro-Costa, Olalla (author);León, Christian David Alcívar (author);Heredia-Moya, Jorge (author)
- Publisher
- MDPI
- Published
- 2020
- Language
- EN
- Category
- nonfiction