Can I read Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques on EtoBox?

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques by Lis de Weerd1*, Selina Hummel2, Stephan A. Müller1,7, Iñaki Paris1, Thomas Sandmann3, Marie Eichholtz6, is a book available to read on EtoBox.

What is Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques about?

AbstractAnti-amyloid β-peptide (Aβ) immunotherapy was developed to reduce amyloid plaque pathology and slow cognitive decline during progression of Alzheimer’s disease. Efficient amyloid clearance has been proven in clinical trials testing anti-Aβ antibodies, by their impact on cognitive endpoints correlating with the extent of amyloid removal. However, treatment is associated with adverse side effects, such as oedema and haemorrhages, which are potentially linked to the induced immune response. To improve the safety profile of these molecules, it is imperative to understand the consequences of anti-Aβ antibody treatment on immune cell function. Here, we investigated the effects of long-term chronic anti-Aβ treatment on amyloid plaque pathology and microglial response in the APP-SAA triple knock-in mouse model with an intervention paradigm early during amyloidogenesis. Long-term treatment with anti-Aβ results in a robust and dose-dependent lowering of amyloid plaque pathology, with a higher efficiency for reducing diffuse over dense-core plaque deposition. Analysis of the CSF proteome indicates a reduction of markers for neurodegeneration including Tau and α-Synuclein, as well as i

Author

Lis de Weerd1*, Selina Hummel2, Stephan A. Müller1,7, Iñaki Paris1, Thomas Sandmann3, Marie Eichholtz6,

Published

2025

Language

EN