Can I read Lessons from antiamyloid-β immunotherapies in Alzheimer's disease on EtoBox?

Lessons from antiamyloid-β immunotherapies in Alzheimer's disease by Germán Plascencia-Villa; George Perry is a book available to read on EtoBox.

What is Lessons from antiamyloid-β immunotherapies in Alzheimer's disease about?

The amyloid hypothesis, that established amyloid-b (Ab) peptide as the primary cause of Alzheimer's disease (AD) and related dementia, has driven the development of treatments for neurodegeneration for 30 years. During the last decades, more than 200 clinical trials testing more than 30 anti-Ab immunotherapies have been assessed as potential treatments for AD. Avaccine against Abwas the first immunotherapy intended to avoid aggregation of Ab into fibrils and senile plaques, but it dramatically failed. Several other vaccines have been proposed as potential AD treatments, targeting different domains or structural motifs of Ab aggregates, but without clear clinical benefits or effectiveness. In contrast, anti-Ab therapeutic antibodies have focused on recognizing and removing Ab aggregates (oligomers, fibrils, or plaques) by eliciting immune clearance. In 2021, the first anti-Ab antibody, aducanumab (branded as Aduhelm), received FDA approval under an accelerated approval process. The effectiveness and the overall processes regarding the approval of Aduhelm have been under major criticism and scrutiny, prompting a vote of no confidence by public and private health providers, limiting t

Author

Germán Plascencia-Villa; George Perry

Publisher

Elsevier - Health Sciences Division

Published

2023

Language

EN

ISBN

9780323855556

Subjects

Psychology, Medical, Science