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Can I read Protein Tyrosine Kinases: From Inhibitors to Useful Drugs (Cancer Drug Discovery and Development) on EtoBox?
Protein Tyrosine Kinases: From Inhibitors to Useful Drugs (Cancer Drug Discovery and Development) by Mark Pearson PhD, Carlos García-Echeverría PhD (auth.), Doriano Fabbro PhD, Frank McCormick MD, PhD (eds.) is a nonfiction available to read on EtoBox.
What is Protein Tyrosine Kinases: From Inhibitors to Useful Drugs (Cancer Drug Discovery and Development) about?
Protein kinases function as components of signal transduction pathways, playing a central role in the control of cell growth, metabolism, differentiation, and apoptosis. The development of selective protein tyrosine kinase (PTK) inhibitors that can block or modulate diseases, such as cancer, with abnormalities in these signaling pathways is considered a promising approach for drug development. Currently, more than 20 different PTKs are being considered as potential therapeutic targets in oncology. In Protein Tyrosine Kinases: From Inhibitors to Useful Drugs, leading researchers from the Novartis group that pioneered Gleevec/GlivecTM and from around the world comprehensively survey the state-of-the-art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made toward generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of
Who reads Protein Tyrosine Kinases: From Inhibitors to Useful Drugs (Cancer Drug Discovery and Development)?
It is typically read by self-directed learners exploring a subject in depth.
Common subject areas: history, science, philosophy, social sciences.
- Author
- Mark Pearson PhD, Carlos García-Echeverría PhD (auth.), Doriano Fabbro PhD, Frank McCormick MD, PhD (eds.)
- Publisher
- Humana Press
- Published
- 2006
- Language
- EN
- ISBN
- 9781592599622
- Category
- nonfiction
- Subjects
- Science, Chemistry, Medical
Other editions & translations
More by Mark Pearson PhD, Carlos García-Echeverría PhD (auth.), Doriano Fabbro PhD, Frank McCormick MD, PhD (eds.)
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