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What is Novel Mucoadhesive Polymers for Nasal Drug Delivery about?

Nasal drug administration is attractive noninvasive approach to rapidly achieve local or systemic effects of small molecular drugs, proteins, and peptides, as well as for nasal immunization and nose-to-brain targeted delivery. However, conventional nasal dosage forms such as nasal drops, sprays, and nasal powders, are often suboptimal to provide bioavailability higher than 10% of drug molecules with high lipophilicity, hydrophilicity, or molecular mass, due to the nasal mucociliary clearance mechanism. The most extensively investigated formulation strategy for improving nasal bioavailability is the development of mucoadhesive drug delivery systems. Novel nasal liquid preparations with in situ gelling polymers have been proposed as a promising concept suitable for convinient instillation, precise dosing, good spreadability, enhanced nasal retention, and achievement of controlled drug release. Furthermore, mucoadhesive polymeric nanoparticles (up to 300 nm) have been evaluated as carriers for increased nose-to-brain bioavailability. This chapter reviews widely used mucoadhesive polymers and their derivatives considered so far as components of nasal drug delivery systems, including: n

Author

Ljiljana Djekic

Publisher

Springer International Publishing AG

Published

2023

Language

EN

ISBN

9783031231117

Subjects

Medical, Technology, Science