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Effect of Metformin Use on Vitamin B12 Deficiency Over Time (EMBER): A Real-World Evidence Database Study 1 Introduction 1 Methods 2 The All of Us Research Platform 2 Study Population 2 Primary Outcome: Vitamin B12 Deficiency 2 Highlights 2 Clinical Relevance 2 Covariates 3 Statistical Analysis 3 Results 3 Self-Reported Outcomes: Physical Health and Medication History 4 Baseline Vitamin B12 Measurements 5 Impact of Metformin on Vitamin B12 Level 5 Discussion 5 Conclusion 6 Disclosure 6 Acknowledgment 6 References 6
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