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Focus on Vitamin B12:Present Knowledge and Future Opportunities 1 Slide Number 2 2 The conquest of Pernicious Anemia & the characterization of vitamin B12 3 Slide Number 4 4 Vitamin B12: Pernicious Anemia and beyond 5 Slide Number 6 6 Slide Number 7 7 Vitamin B-12 (cobalamin) metabolism 8 NIH’s Biomarkers for Nutrition & Development (BOND): B12 Expert Panel 9 NIH’s Biomarkers for Nutrition & Development (BOND): B12 Expert Panel: serum B12 cut-points 10 NIH’s Biomarkers for Nutrition & Development (BOND): the 3 other markers of B12 status 11 Causes of B12 deficiency 12 Dietary sources of B12 (RDA = 2.4 ug/d)(NONE in any plant source foods) 13 Mean B12 intakes of men by diet groups, EPIC (Davey, 2002) 14 Serum B-12 (pmol/L) vs. usual diet 15 Slide Number 16 16 % B12 absorbed is inversely proportional to dose (Chanarin) 17 % B12 absorbed is inversely proportional to dose (Chanarin) 18 Percent of energy in food supply from animal source foods (ASF) predicts B12 status 19 Malabsorption 20 NHANES III: Prevalence of deficient and marginal serum B12 (Pfeiffer et al. 2007) 21 Prevalence of B12 deficiency 22 Slide Number 23 23 Consequences of B12 deficiency – does it matter? 24 Stag

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lindsay.allen
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