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Oxidized bacterial cellulose reinforced nanocomposite scaffolds for bone repair 1 1 Introduction 1 2 Materials and methods 2 2.1 Materials 2 2.2 Preparation of CS/OBC/nHAP scaffolds 2 2.3 Morphology and composition analysis of scaffolds 2 2.4 Porosity test 2 2.5 Swelling ratio 2 2.6 In vitro degradation 2 2.7 In vitro biomineralization 2 2.8 Cytocompatibility 2 2.8.1 AO/EB assay 2 2.8.2 CCK-8 assay 2 2.9 In vivo repair of rat skull defect 3 2.10 Statistical analysis 4 3 Result and discussion 4 3.1 Preparation mechanism of CS/OBC/nHAP scaffolds 4 3.2 Morphology and composition analysis of CS/OBC/nHAP scaffolds 5 3.3 Properties of CS/nHAP and CS/OBC/nHAP scaffolds 5 3.4 In vitro biomineralization 6 3.5 In vitro cytocompatibility 8 3.6 In vivo repair of rat skull defect 8 4 Conclusion 8 CRediT authorship contribution statement 8 Declaration of Competing Interest 8 Acknowledgement 8 Declaration of interests 8 References 8

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nonfiction