Can I read Development of electrocardiogram intervals during growth of FVB/N neonate mice on EtoBox?

Development of electrocardiogram intervals during growth of FVB/N neonate mice by Christopher R Heier; Thomas G Hampton; Deli Wang; Christine J DiDonato is a Medicine article available to read on EtoBox.

What is Development of electrocardiogram intervals during growth of FVB/N neonate mice about?

## Abstract ## Background Electrocardiography remains the best diagnostic tool and therapeutic biomarker for a spectrum of pediatric diseases involving cardiac or autonomic nervous system defects. As genetic links to these disorders are established and transgenic mouse models produced in efforts to understand and treat them, there is a surprising lack of information on electrocardiograms (ECGs) and ECG abnormalities in neonate mice. This is likely due to the trauma and anaesthesia required of many legacy approaches to ECG recording in mice, exacerbated by the fragility of many mutant neonates. Here, we use a non-invasive system to characterize development of the heart rate and electrocardiogram throughout the growth of conscious neonate FVB/N mice. ## Results We examine ECG waveforms as early as two days after birth. At this point males and females demonstrate comparable heart rates that are 50% lower than adult mice. Neonatal mice exhibit very low heart rate variability. Within 12 days of birth PR, QRS and QTc interval durations are near adult values while heart rate continues to increase until weaning. Upon weaning FVB/N females quickly develop slower heart rates than males, thou

Who reads Development of electrocardiogram intervals during growth of FVB/N neonate mice?

Author

Christopher R Heier; Thomas G Hampton; Deli Wang; Christine J DiDonato

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1472-6793)

Published

2010

Language

EN

Field

Medicine (Life Sciences)