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Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: Implication for whole bladder wall photodynamic therapy by Appolinary A.R. Kamuhabwa; Isabelle Cosserat‐Gerardin; Jacques Didelon; Dominique Notter; François Guillemin; Tania Roskams; Marie‐Ange D'Hallewin; Luc Baert; Peter A.M. de Witte is a Medicine article available to read on EtoBox.
What is Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: Implication for whole bladder wall photodynamic therapy about?
## Abstract In a recent clinical study, we reported a selective uptake of hypericin in superficial bladder tumors. The results suggested that hypericin, a potent photosensitizer, could be used not only for diagnosis but also for photodynamic therapy (PDT) of superficial bladder tumors. In the present study, we investigated the biodistribution of hypericin in an orthotopic rat bladder tumor model by assessing the extent of hypericin penetration and the kinetics of accumulation into rat bladder tumors and normal bladder wall. Hypericin (8 or 30 μM) was instilled into the bladder via the catheter for 1, 2 or 4 hr. The fluorescence of hypericin in the bladder tumors and normal bladder was documented using fluorescence microscopy. __In situ__ quantification of hypericin fluorescence in the tumor or normal bladder was performed using the laser‐induced fluorescence technique. There was much more hypericin fluorescence in the tumor than in the normal bladder, with the tumor‐to‐normal‐bladder ratio mounting to 12:1 after 4 hr of hypericin (30 μM) instillation. Moreover, hypericin was retained in the tumor for at least 1 hr before it was gradually lost from the tissue. Microscopically, the f
Who reads Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: Implication for whole bladder wall photodynamic therapy?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Appolinary A.R. Kamuhabwa; Isabelle Cosserat‐Gerardin; Jacques Didelon; Dominique Notter; François Guillemin; Tania Roskams; Marie‐Ange D'Hallewin; Luc Baert; Peter A.M. de Witte
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)