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The study investigates the role of the non-canonical Cullin-4A/4BCDT2 E3 ubiquitin ligase in modulating post-replication repair (PRR) and cell survival during DNA replication in mammalian cells. It reveals that down-regulation of Cullin-4CDT2 activates DNA damage response (DDR) markers and leads to replication stress, highlighting its essential function in preventing apoptosis during unperturbed S-phase. The findings suggest that the Cullin-4CDT2 complex interacts with RAD18 to regulate PCNA monoubiquitylat
- Author
- muzim
- Language
- EN