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Abnormal Cytogenetic Clones in Patients with Aplastic Anaemia: Response to Immunosuppressive Therapy by C. G. Geary; C. J. Harrison; N. J. Philpott; J. M. Hows; E. C. Gordon-Smith; J. C. W. Marsh is a scholarly article available to read on EtoBox.

What is Abnormal Cytogenetic Clones in Patients with Aplastic Anaemia: Response to Immunosuppressive Therapy about?

We report the response to immunosuppressive therapy with antithymocyte globulin (ATG) and cyclosporin or oxymetholone in 13 cases of aplastic anaemia (AA) with an abnormal cytogenetic clone detected at or sometime after diagnosis. Blood and bone marrow examination showed no distinctive morphological features of myelodysplasia (MDS) at diagnosis. Haematological response occurred promptly in eight cases; the remainder responded after additional immunosuppression with or without oxymetholone. Three patients had a late relapse of AA, treated successfully by allogeneic bone marrow transplantation in one; the others responded to oxymetholone. Transformation to MDS or acute leukaemia was not observed after a median follow‐up of 4.1 years (range 1.2–11.2). In four patients the cytogenetic clone disappeared after treatment.

Author

C. G. Geary; C. J. Harrison; N. J. Philpott; J. M. Hows; E. C. Gordon-Smith; J. C. W. Marsh

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

1999

Language

EN