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Dasatinib impairs platelet production both at steady state and under conditions requiring an acute increase in thrombopoiesis. Treatment with dasatinib increases the number of megakaryocytes (MKs) in bone marrow but does not reduce MK numbers. Dasatinib promotes MK differentiation but may impair the final stages of platelet production by inhibiting MK migration and proplatelet formation. In vitro studies demonstrate dasatinib increases MK ploidy and the percentage of MKs, consistent with increased megakaryo

Author

Amar A. Lubis

Language

EN