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Direct Analysis of Fluoxetine and Norfluoxetine in Plasma by Gas Chromatography with Nitrogen-phosphorus Detection by P. Fontanille; N. Jourdil; C. Villier; G. Bessard is a scholarly article available to read on EtoBox.

What is Direct Analysis of Fluoxetine and Norfluoxetine in Plasma by Gas Chromatography with Nitrogen-phosphorus Detection about?

A quantitative method for the simultaneous GC resolution and detection of fluoxetine and his metabolite norfluoxetine in human plasma was developed. The procedure required 1.0 ml of plasma, extraction with a mixed organic solvent and injection into a capillary gas chromatograph with an OV-1 fused-silica column coupled to a nitrogen-phosphorus detector. The calibration curves were linear over the range 5-3000 ng/ml. The detection limits were 0.3 and 2 ng/ml for fluoxetine and norfluoxetine, respectively. The assay is suitable for routine analysis.

Author

P. Fontanille; N. Jourdil; C. Villier; G. Bessard

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-4347)

Published

1997

Language

EN