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Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC by Holger Heine; Sven Müller-Loennies; Lore Brade; Buko Lindner; Helmut Brade is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC about?
The lipopolysaccharide (LPS) of __Chlamydia trachomatis__ serotype E was isolated from tissue culture‐grown elementary bodies and analyzed structurally by mass spectrometry and ^1^H, ^13^C and ^31^P nuclear magnetic resonance. The LPS is composed of the same pentasaccharide bisphosphate αKdo‐(2–8)‐αKdo‐(2–4)‐αKdo‐(2–6)‐βGlcN‐4P‐(1–6)‐αGlcN‐1P (Kdo is 3‐deoxy‐α‐d‐__manno__‐oct‐2‐ulosonic acid) as reported for __C. trachomatis__ serotype L~2~[Rund, S., Lindner, B., Brade, H. and Holst, O. (1999) __J. Biol. Chem.__ 274, 16819–16824]. The glucosamine disaccharide backbone is substituted with a complex mixture of fatty acids with ester or amide linkage whereby no ester‐linked hydroxy fatty acids were found. The LPS was purified carefully (with contaminations by protein or nucleic acids below 0.3%) and tested for its ability to induce proinflammatory cytokines in several readout systems in comparison to LPS from __C. trachomatis__ serotype L~2~ and __Chlamydophila psittaci__ strain 6BC as well as enterobacterial smooth and rough LPS and synthetic hexaacyl lipid A. The chlamydial LPS were at least 10 times less active than typical endotoxins; specificity of the activities was confirmed by
Who reads Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Holger Heine; Sven Müller-Loennies; Lore Brade; Buko Lindner; Helmut Brade
- Publisher
- John Wiley and Sons; Springer; Wiley (Blackwell Publishing); Springer-Verlag; Blackwell Publishing Inc.; Springer Verlag; Wiley; Springer Science and Business Media LLC (ISSN 1432-1327)
- Published
- 2003
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)