Can I read Mechanistic Evaluation Of Ursolic Acid Against Rotenone Induced Parkinson’s Disease– Emphasizing The Role Of Mitochondrial Biogenesis on EtoBox?

Mechanistic Evaluation Of Ursolic Acid Against Rotenone Induced Parkinson’s Disease– Emphasizing The Role Of Mitochondrial Biogenesis by Peshattiwar, Vaibhavi; Muke, Suraj; Kaikini, Aakruti; Bagle, Sneha; Dighe, Vikas; Sathaye, Sadhana is a scholarly article available to read on EtoBox.

What is Mechanistic Evaluation Of Ursolic Acid Against Rotenone Induced Parkinson’s Disease– Emphasizing The Role Of Mitochondrial Biogenesis about?

Parkinson's disease (PD) is an age associated, progressive and a second most common neurodegenerative disease. It is caused due to degeneration of dopaminergic neurons in substantia nigra (SN). Various studies implicate mitochondrial dysfunction, oxidative stress, altered degradation of misfolded proteins in PD pathogenesis. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is reported to possess a number of biological activities viz. anti-oxidant, anti-inflammatory etc. The focus of our study was to assess the neuroprotective potential of UA against the rotenone induced pathophysiological alterations. In this study rats were subjected to stereotaxic bilateral injection of rotenone (12 μg/μl) in SN. Further, they were treated per-orally with UA (5 and 10 mg/kg) for 30 days. During the study, neurobehavioral tests comprising Rota-rod, Open field and Barnes maze (BMT) were conducted. At the end of 30 days, the antioxidant (Reduced glutathione, superoxide dismutase, catalase and lipid peroxidation), inflammatory (TNF-α) parameters, mitochondrial complex I, mitochondrial biogenesis (MB) and immunohistochemical analysis (TH positive neurons, Glial Fibrillary Acidic

Author

Peshattiwar, Vaibhavi; Muke, Suraj; Kaikini, Aakruti; Bagle, Sneha; Dighe, Vikas; Sathaye, Sadhana

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0361-9230)

Published

2020

Language

EN