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Asymmetric Michael Reaction of Alkynyl Ketones by ruthnapitu2006 is a document available to read on EtoBox.
This article presents a novel asymmetric Michael reaction of methyl alkynyl ketone and α,β-unsaturated aldehyde, catalyzed by diphenylprolinol silyl ether, yielding δ-oxo aldehydes with high enantioselectivity. The reaction demonstrates the utility of methyl alkynyl ketones as both Michael donors and acceptors, leading to valuable chiral building blocks for further synthesis, including a key intermediate for atorvastatin. The study highlights the efficiency of a two-pot synthesis method to produce the desir
- Author
- ruthnapitu2006
- Language
- EN