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Intravascular Tumor Necrosis Factor α Blockade Reverses Endothelial Dysfunction in Rheumatoid Arthritis by CARDILLO, C; SCHINZARI, F; MORES, N; METTIMANO, M; MELINA, D; ZOLI, A; FERRACCIOLI, G is a scholarly article available to read on EtoBox.

What is Intravascular Tumor Necrosis Factor α Blockade Reverses Endothelial Dysfunction in Rheumatoid Arthritis about?

## Background: Patients with rheumatoid arthritis (ra) have endothelial dysfunction, which may predispose them to the risk of premature atherosclerosis. this study investigated the involvement of tumor necrosis factor (tnf) alpha in the pathophysiologic characteristics of this abnormality by use of the tnf-alpha-neutralizing antibody infliximab. ## Methods: Endothelium-dependent and -independent vasodilator responses to intra-arterial infusion of increasing doses of acetylcholine and sodium nitroprusside, respectively, were assessed by strain-gauge plethysmography in patients (n = 10) with early ra during saline solution infusion and after intra-arterial infusion of infliximab (200 microg/min). ## Results: Circulating markers of systemic inflammation (c-reactive protein and interleukin 6) were higher in patients than in control subjects (n = 10, both p .05). during saline solution infusion, the vasodilator response to acetylcholine was blunted in patients with ra compared with control subjects (14.2 +/- 9.2 ml . min-(1). dl-(1) versus 23.7 +/- 9.2 ml . min-(1). dl-(1) at the highest dose, p = .004) whereas vasodilation to sodium nitroprusside was not different between groups (p =

Author

CARDILLO, C; SCHINZARI, F; MORES, N; METTIMANO, M; MELINA, D; ZOLI, A; FERRACCIOLI, G

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)

Published

2006

Language

EN