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Can I read Decreased plasma H~2~O~2~ levels are associated with the pathogenesis leading to COVID-19 worsening and mortality on EtoBox?
Decreased plasma H~2~O~2~ levels are associated with the pathogenesis leading to COVID-19 worsening and mortality by Liara Freitas Cavalcanti; Isabela Chagas Silva; Thiago Henrique Daniel do Nascimento; Jôse de Melo; Cintia Magalhães Carvalho Grion; Alessandra Lourenço Cecchini; Rubens Cecchini is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Decreased plasma H~2~O~2~ levels are associated with the pathogenesis leading to COVID-19 worsening and mortality about?
Oxidative Stress (OS) is involved in the pathogenesis of COVID-19 and in the mechanisms by which SARS-CoV-2 causes injuries to tissues, leading to cytopathic hypoxia and ultimately multiple organ failure. The measurement of blood glutathione (GSH), H 2 O 2 , and catalase activity may help clarify the pathophysiology pathways of this disease. We developed and standardized a sensitive and specific chemiluminescence technique for H 2 O 2 and GSH measurement in plasma and red blood cells of COVID-19 patients admitted to the intensive care unit (ICU). Contrary to what was expected, the plasma concentration of H 2 O 2 was substantially reduced (10-fold) in COVID-19 patients compared to the healthy control group. From the cohort of patients discharged from the hospital and those who were deceased, the former showed a 3.6-fold and the later 16-fold H 2 O 2 reduction compared to the healthy control. There was a 4.4 reduction of H 2 O 2 concentration in the deceased group compared to the discharged group. Interestingly, there was no variation in GSH levels between groups, and reduced catalase activity was found in discharged and deceased patients compared to control. These data represent str
Who reads Decreased plasma H~2~O~2~ levels are associated with the pathogenesis leading to COVID-19 worsening and mortality?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Liara Freitas Cavalcanti; Isabela Chagas Silva; Thiago Henrique Daniel do Nascimento; Jôse de Melo; Cintia Magalhães Carvalho Grion; Alessandra Lourenço Cecchini; Rubens Cecchini
- Publisher
- Informa UK Limited
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)