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BRCA1/2 carriers: their childbearing plans and theoretical intentions about having preimplantation genetic diagnosis and prenatal diagnosis by Claire Julian-Reynier; Roxane Fabre; Isabelle Coupier; Dominique Stoppa-Lyonnet; Christine Lasset; Olivier Caron; Emmanuelle Mouret-Fourme; Pascaline Berthet; Laurence Faivre; Marc Frenay; Paul Gesta; Laurence Gladieff; Anne-Deborah Bouhnik; Christel Protière; Catherine Noguès is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is BRCA1/2 carriers: their childbearing plans and theoretical intentions about having preimplantation genetic diagnosis and prenatal diagnosis about?

## Purpose: To assess the impact of __BRCA1/2__ test results on carriers' reproductive decision-making and the factors determining their theoretical intentions about preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PND). ## Methods: Unaffected __BRCA1/2__ mutation carriers of childbearing age (__N__ = 605; 449 women; 151 men) were included at least 1 year after the disclosure of their test results in a cross-sectional survey nested in a national cohort. Multivariate adjustment was performed on the data obtained in self-administered questionnaires. ## Results: Response rate was 81.0%. Overall, 32.5% and 50% said that they would undergo PGD/PND, respectively, at a theoretical next pregnancy, whereas only 12.1% found termination of pregnancy (TOP) acceptable. Theoretical intentions toward PGD did not depend on gender/age, but were higher among those with no future childbearing plans (adjusted odds ratio (AOR) 95% confidence interval (CI): 3.5 (1.9–6.4)) and those having fewer relatives with cancer (AOR 1.5 95% CI (1.0–2.3)). Greater TOP acceptability was observed among males and those with lower educational levels; 85.4% of respondents agreed that information about PGD/

Who reads BRCA1/2 carriers: their childbearing plans and theoretical intentions about having preimplantation genetic diagnosis and prenatal diagnosis?

Author

Claire Julian-Reynier; Roxane Fabre; Isabelle Coupier; Dominique Stoppa-Lyonnet; Christine Lasset; Olivier Caron; Emmanuelle Mouret-Fourme; Pascaline Berthet; Laurence Faivre; Marc Frenay; Paul Gesta; Laurence Gladieff; Anne-Deborah Bouhnik; Christel Protière; Catherine Noguès

Publisher

Elsevier BV

Published

2012

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)