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Can I read BRD2 protects the rat H9C2 cardiomyocytes from hypoxia‐reoxygenation injury by targeting Nrf2/HO‐1 signaling pathway on EtoBox?
BRD2 protects the rat H9C2 cardiomyocytes from hypoxia‐reoxygenation injury by targeting Nrf2/HO‐1 signaling pathway by Yingcun Liu; Yuqing Fu; Xin Xue; Gang Tang; Liangyi Si is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is BRD2 protects the rat H9C2 cardiomyocytes from hypoxia‐reoxygenation injury by targeting Nrf2/HO‐1 signaling pathway about?
Myocardial ischemia-reperfusion (I/R) injury is a common complication of acute myocardial infarction following percutaneous coronary intervention, but there are currently no effective pharmacological targets for adjuvant therapy due to a lack of knowledge of I/R injury mechanisms in cardiomyocytes. To evaluate the effects of hypoxia-reoxygenation on the plasma proteome of cardiomyocytes and prospective therapeutic targets, five sets of H9C2 cardiomyocytes from rats were cultured under various hypoxic circumstances. Using Cell Counting Kit-8 (CCK8) and lactose dehydrogenase (LDH) release assays, the cell viability and LDH release of H9C2 cells were analyzed. Proteome sequencing was then performed on cardiomyocytes to show the quantitative protein changes during the I/R injury process. After hypoxia/reoxygenation, bromodomain-containing protein 2 (BRD2) expression was evaluated. After administering the BRD2 inhibitor dBET1, the expression of nuclear factor erythroid 2-related factor 2/haem oxygenase-1 (Nrf2/HO-1) was identified. The results showed that in the group exposed to 4 h of hypoxia followed by 4 h of reoxygenation (H/R4), the cell survival rate was dramatically reduced, alth
Who reads BRD2 protects the rat H9C2 cardiomyocytes from hypoxia‐reoxygenation injury by targeting Nrf2/HO‐1 signaling pathway?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yingcun Liu; Yuqing Fu; Xin Xue; Gang Tang; Liangyi Si
- Publisher
- Spandidos Publications
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)
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