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Is soluble adenylyl cyclase (sAC) involved in ischemia-reperfusion injury? by Alejandro Ciocci Pardo; Juan Ignacio Elio Mariangelo; Luisa Fernanda González Arbeláez; Juliana Catalina Fantinelli; Ernesto Alejandro Aiello; Susana María Mosca is a scholarly article available to read on EtoBox.

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Conclusions Thus, the relative levels of VIMP and DERLIN1 comprise a molecular switch mechanism that regulates a newly defined non-canonical ERAD-mediated degradation of SGK1, a critical signaling kinase contributing to pathological cardiac hypertrophy. Furthermore, this non-canonical ERAD is of unique importance in cardiomyocytes as these effects of VIMP gain and loss of function were not observed in cardiac fibroblasts from the same mouse hearts.

Author

Alejandro Ciocci Pardo; Juan Ignacio Elio Mariangelo; Luisa Fernanda González Arbeláez; Juliana Catalina Fantinelli; Ernesto Alejandro Aiello; Susana María Mosca

Publisher

Elsevier BV

Published

2022

Language

EN